Cubosomes as a Potential Oral Drug Delivery System for Enhancing the Hepatoprotective Effect of Coenzyme Q10

Coenzyme Q10 (CoQ10) acts as an antioxidant that protects the cells by preventing lipid peroxidation. Owing to its low solubility, CoQ10 has shown poor delivery properties and bioavailability. The aim of this study is develop loaded cubosomes in order enhance oral hepatoprotective activity. Cubosomes are cubic nanostructured systems resulting from colloidal dispersion liquid crystalline structure water. were prepared using poloxamer 407 glyceryl monooleate at three weight ratios (1:2.5, 1:5 1:7.5) further characterized. They investigated for their effect thioacetamide (TAA) induced hepatotoxicity Wistar rats. developed exhibited moderate high entrapment efficiency percentages (44.69–75.96%), nanometric dimensions (132.4–223.2 nm), negatively charged zeta potential values (<-21.3). In-vitro release profiles showed a sustained up 48 h. In-vivo revealed improved via reducing liver enzymes, nitric oxide malondialdehyde well elevating phosphoinositide 3-kinase, catalase glutathione peroxidase, compared plain drug. These results good agreement with histopathological investigations. Consequently, enhancing activity CoQ10.